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Headache response at 2 hours was 62%for zolmitriptan compared with 36%for placebo(p<0.001);at 4 hours,headache response was 70%with zolmitriptan and 37%with placebo(p<0.001).Headache recurrence in patients treated with 2. 5mg zolmitriptan was 22%(versus placebo 30%).The headache response at 4 hours,pain-free rate,and response rate of nonheadache symptoms favored zolmitriptan over placebo.No serious adverse events were associated with zolmitriptan treatment.A 2.5mg dose of zolmitriptan is clinically effective and well tolerated for the acute treatment of migraine. |
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